By Pedro Fonseca
RIO DE JANEIRO (Reuters) – A new analyze that analyzed the coronavirus outbreak in Brazil has discovered a hyperlink involving the spread of the virus and previous outbreaks of dengue fever that suggests exposure to the mosquito-transmitted health issues may possibly supply some stage of immunity against COVID-19.
The not however printed study led by Miguel Nicolelis, a professor at Duke College, and shared exclusively with Reuters, in contrast the geographic distribution of coronavirus scenarios with the spread of dengue in 2019 and 2020.
Sites with reduced coronavirus infection fees and slower case progress were being places that had endured powerful dengue outbreaks this 12 months or past, Nicolelis uncovered.
“This hanging obtaining raises the intriguing chance of an immunological cross-reactivity among dengue’s Flavivirus serotypes and SARS-CoV-2,” the examine explained, referring to dengue virus antibodies and the novel coronavirus.
“If tested correct, this hypothesis could suggest that dengue infection or immunization with an efficacious and harmless dengue vaccine could develop some degree of immunological protection” in opposition to the coronavirus, it included.
Nicolelis advised Reuters the final results are particularly interesting mainly because preceding studies have revealed that people with dengue antibodies in their blood can examination falsely beneficial for COVID-19 antibodies even if they have never ever been contaminated by the coronavirus.
“This signifies that there is an immunological conversation among two viruses that nobody could have predicted, due to the fact the two viruses are from absolutely different households,” Nicolelis claimed, incorporating that further more reports are essential to prove the relationship.
The examine was getting released ahead of peer evaluation on the MedRxiv preprint server and will be submitted to a scientific journal.
It highlights a major correlation concerning reduced incidence, mortality and growth amount of COVID-19 in populations in Brazil where by the degrees of antibodies to dengue were increased.
Brazil has the world’s third maximum complete of COVID-19 bacterial infections with more than 4.4 million situations – behind only the United States and India.
In states these types of as Paraná, Santa Catarina, Rio Grande do Sul, Mato Grosso do Sul and Minas Gerais, with a substantial incidence of dengue final year and early this calendar year, COVID-19 took substantially lengthier to achieve a level of high group transmission in comparison to states these as Amapá, Maranhão and Pará that had much less dengue situations.
The crew discovered a equivalent marriage amongst dengue outbreaks and a slower spread of COVID-19 in other components of Latin The united states, as very well as Asia and islands in the Pacific and Indian Oceans.
Nicolelis said his crew came across the dengue discovery by incident, throughout a research centered on how COVID-19 had distribute by way of Brazil, in which they found that highways performed a big purpose in the distribution of circumstances throughout the nation.
After identifying selected scenario-absolutely free places on the map, the staff went in lookup of attainable explanations. A breakthrough arrived when the workforce in comparison the distribute of dengue with that of the coronavirus.
“It was a shock. It was a whole incident,” Nicolelis said. “In science, that takes place, you happen to be shooting at one particular thing and you strike a goal that you never ever imagined you would strike.”
(Reporting by Pedro Fonseca producing by Stephen Eisenhammer Editing by Bill Berkrot)